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Discusses the origin of the heart rate and sinus rhythm. A number of physiological manoeuvres are performed to illustrate the way in which the heart responds to the demands of the circulation. Animated...
Preparation: guinea pig ileum. Describes the isolated organ response recording technique and includes setting up procedures of the mammalian intestine preparation, the principles of isolated organ...
Preparation: guinea-pig ileum. The reasons for engaging in biological methods for the estimation of drug potency are stated as well as the requirements for the successful carrying out of such procedures. The...
Studies effects of autonomic drugs and blocking agents on the components of the cardiovascular system in vivo. The cardiovascular system of an animal is a closed system in which a pump (the heart) forces...
Preparation: rat phrenic nerve diaphragm. Gives a detailed historical background to the discovery of muscle relaxant drugs and summarises the results of the early experiments conducted by Claude Bernard. The...
Preparation: perfused rat mesentery. The method of constant volume perfusion of a vascular preparation is demonstrated as well as the measurement of changes in vascular resistance using pressure transducers....
Demonstrates the effect of autonomic drugs on the isolated perfused mammalian heart. The mammalian heart is innervated through both the sympathetic and parasympathetic nervous system and will therefore...
Demonstrates the responses of the cat to blood pressure changes including heart rate and the smooth muscle responses of the nictitating membrane. Shows the sympathetic nerve innovation and the effects of...
Preparation: guinea-pig ileum. Non-competitive antagonism can arise from either non-equilibrium receptor blockade or inhibition of an intracellular process distal to the site of agonist receptor action. The...
Preparation: guinea pig ileum. The presentation includes a brief theoretical introduction to the possible sites of drug action on the longitudinal smooth muscle layer of the intestine, based on a...
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