Non-Competitive Antagonism

Synopsis

Preparation: guinea-pig ileum. Non-competitive antagonism can arise from either non-equilibrium receptor blockade or inhibition of an intracellular process distal to the site of agonist receptor action. The Biovideograph section shows the obtaining of log dose response relationships to the agonists histamine and acetylcholine. Non-competitive antagonism is produced as a result of a single incubation of the preparation with phenoxybenzamine. The differential irreversible inactivation of the receptor population is demonstrated by the extent of the reduction in the maximal agonist response magnitude as well as the rightward shift of the log dose response curves to histamine and acetylcholine. The concluding part of the programme contains a commentary on the distinguishing features of competitive and non-competitive antagonism.

Language

English

Country

Great Britain

Medium

Video; Videocassette. Standard formats (for use with Biovideograph). col. 59 min.

Year of production

198

Availability

OUT OF DISTRIBUTION

Subjects

Biology

Keywords

guinea pigs; ileum; laboratory experiments

Production Company

Name

University of Bradford

Distributor

Name

Harvard Apparatus

Phone

01732 864001

Address

Fircroft Way
Edenbridge
Kent
TN8 6HE

Notes

No longer distributes videos (5/96)