Effects of Neuromuscular Blocking Agents on the Rat Phrenic Nerve Diaphragm

Synopsis

Preparation: rat phrenic nerve diaphragm. Gives a detailed historical background to the discovery of muscle relaxant drugs and summarises the results of the early experiments conducted by Claude Bernard. The experimental set up of the phrenic nerve diaphragm preparation is shown. The Biovideograph section demonstrates the differential effects of muscle relaxant addition to nerve mediated responses and the absence of action on direct electrical stimulation of the muscle. Using responses to the addition of K+, nerve induced tetanic responses, post-tetanic stimulation events and the addition of the anticholinesterase neostignine, a classification of muscle relaxant action into non-depolarising/competitive and depolarising types is described.

Language

English

Country

Great Britain

Medium

Video; Videocassette. Standard formats (for use with Biovideograph). col. 50 min.

Year of production

198

Availability

OUT OF DISTRIBUTION

Subjects

Medical sciences

Keywords

central nervous system; laboratory animals; laboratory experiments; muscle relaxants; rats

Production Company

Name

University of Bradford

Distributor

Name

Harvard Apparatus

Phone

01732 864001

Address

Fircroft Way
Edenbridge
Kent
TN8 6HE

Notes

No longer distributes videos (5/96)