Relationship Between Agonist Concentrations and the Magnitude of the Response, The (2 Parts)

Synopsis

Preparation: guinea pig ileum. Describes the isolated organ response recording technique and includes setting up procedures of the mammalian intestine preparation, the principles of isolated organ preservation and the method of recording tension changes. Gives theoretical consideration to agonist receptor interactions together with development of the concept of receptor occupancy and the derivation of the Clark equation. The Biovideograph record includes details of the drug administration cycle and the initial steps in the conditioning of the preparation to ensure response reproducibility and submaximal responsiveness. Shows the increase in response magnitude resulting from administration of a range of agonist doses varying from threshold to maximum concentrations. The final section summarises the quantitative treatment of the experimental results and the conclusions which can be drawn.

Language

English

Country

Great Britain

Medium

Video; Videocassette. Standard formats (for use with Biovideograph). col. 53, 20 min.

Year of production

1980

Availability

OUT OF DISTRIBUTION

Subjects

Medical sciences

Keywords

ileum; laboratory experiments; physiology - animal

Production Company

Name

University of Bradford

Distributor

Name

Harvard Apparatus

Phone

01732 864001

Address

Fircroft Way
Edenbridge
Kent
TN8 6HE

Notes

No longer distributes videos (5/96)