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Preparation: guinea-pig ileum. Non-competitive antagonism can arise from either non-equilibrium receptor blockade or inhibition of an intracellular process distal to the site of agonist receptor action. The...
Preparation: guinea pig ileum. The presentation includes a brief theoretical introduction to the possible sites of drug action on the longitudinal smooth muscle layer of the intestine, based on a...
Shows in detail the dissection of a ‘zig-zag’ strip and comments on its merits as opposed to the more laboriously prepared tracheal chain: the tissue is shown responding to carbachol.
Intended to demonstrate commonly used methods for the experimental testing for local anaesthesia in a lecture. The three techniques demonstrated are the frog plexus, the rabbit cornea and the guinea pig...
Preparation: guinea pig ileum. The theoretical derivation is shown of the equation relating response magnitude to the combined presence in the bathing fluids of agonist and competitive antagonist. The...
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