Effects of Drugs on the Skeletal Neuromuscular Junction

Synopsis

The two chief isolated organ preparations for demonstrating the actions of skeletal muscle relaxant drugs are the rat phrenic-nerve diaphragm and the frog rectus abdominis. Both are demonstrated and their principal responses to muscle relaxants are shown. The ability to selectively inhibit nervously evoked contractions, reversal of tubocurarine effects by K+ and eserine and tetanus are shown on the rat diaphragm. The antagonism of acetylcholine contracture by tubocurarine is shown on the frog rectus abdominis as well as the direct stimulatory action of suxamethonium. The failure of tetanus, K+ or eserine to reverse the actions of suxamethonium is also demonstrated on the diaphragm preparations. Explains the concept of competitive and depolarising actions to explain the respective muscle relaxant actions of tubocurarine and suxamethonium.

Language

English

Country

Great Britain

Medium

Video; Videocassette. Standard formats. col. 41 min.

Year of production

1970

Availability

OUT OF DISTRIBUTION

Subjects

Medical sciences

Keywords

central nervous system; frogs; laboratory animals; muscle relaxants; physiology - animal; rats

Credits

Cast

G D H Leach

Distributor

Name

Harvard Apparatus

Phone

01732 864001

Address

Fircroft Way
Edenbridge
Kent
TN8 6HE

Notes

No longer distributes videos (5/96)