Learning on ScreenMetabolism and Function of Vitamin D
- Synopsis
- Vitamin D undergoes in the body a double hydroxylation before it is turned into an active substance, 1,25-dihydroxycholecalciferol, resembling a steroid hormone. The first hydroxylation at carbon 25 occurs preferentially in the liver but also in other organs. The second hydroxylation at carbon 1 is performed uniquely by the kidney and is under an exacting control mechanism which includes the parathyroid hormone. Chronic renal failure results in impaired formation of 1,25-dihydroxycholecalciferol, the kidney hormone, and causes osteodystrophy. Substitution therapy with 1,25-dihydroxycholecalciferol, or its synthetic analogue, 1 alpha-hydroxycholecalciferol, in oral doses of 1-2 mg/day is very successful.
- Series
- Scientific Basis of Medicine, Series
- Language
- English
- Country
- Great Britain
- Medium
- Video; Videocassette. U-matic, VHS. b&w. 37 min.
- Year of production
- 1974
- Availability
- Sale
- Uses
- Postgraduate audiences in medical and biological sciences.
- Subjects
- Medical sciences
- Keywords
- metabolism; physiology - human; vitamin D
Credits
- Director
- David Sharp
- Producer
- David Sharp
- Writer
- E Kodicek
- Cast
E Kodicek
Production Company
- Name
University of London Audio-Visual Centre
- Notes
- Closed down.
Sponsor
- Name
British Postgraduate Medical Federation
- Phone
- 071-831 7599
- Address
- 33 Millman Street
LONDON
WC1N 3EJ
Distributor
- Name
Wellcome Film
- misc@wellcome.ac.uk
- Web
- http://wellcomelibrary.org/about-us/about-the-collections/moving-image-and-sound-collection/ External site opens in new window
- Phone
- 020 7611 8766
- Fax
- 020 7611 8577
- Address
- Moving Image & Sound Collections
Wellcome Library
183 Euston Road
London
NW1 2BE
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