Engineered Zinc Finger Proteins (Zfps) For the Regulation of Gene Expression

Synopsis: Video recording of the 2007 Croonian lecture given at the Royal Society on 3/5/2007. It has long been the goal of molecular biologists to design DNA binding proteins for the specific control of gene expression. The zinc finger design, discovered by Sir Aaron Klug 20 years ago, is ideally suited for such purposes, discriminating between closely related sequences both in vitro and in vivo. Whereas other DNA binding proteins generally make use of the 2-fold symmetry of the double helix, zinc fingers do not, and so can be linked linearly in tandem to recognise DNA sequences of different lengths, with high fidelity and affinity.

In this lecture, Nobel Prize winner Sir Aaron Klug discusses recent developments including trials using VEGF-activating ZFPs to treat human peripheral arterial disease by stimulating vascular growth. Other examples of therapeutic development programs are those on neuropathic pain, macular degeneration and producing permanently modified uninfectable T-cells to combat both HIV and opportunistic infections. 68 minutes.
Language: English
Country: Great Britain
Year of release: 2007
Year of production: 2007
Subjects: Biology
Keywords: DNA sequencing; gene expression; molecular biology; Nobel Prize winners; protein synthesis; Klug, Aaron

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Notes: Royalsociety.tv offers live webcasts as well as podcasts and free, on-demand streaming of video and audio recordings of events held at the Royal Society. Lectures and discussions feature leading scientists and cover history of science as well as exploring cutting-edge science and culture.

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